Iberoamerican Journal of Medicine
Iberoamerican Journal of Medicine
Case Report

Corynebacterium endocarditis in a patient with a cardiac implantable electronic device

Endocarditis por Corynebacterium en un paciente portador de un dispositivo electrónico cardiaco implantable

Sevil Alkan, Uğur Küçük, Serpil Şahin, Taylan Önder

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Cardiac implantable electronic device (CIED) infections have been rising around the world. Many microorganisms can lead to this disease. Corynebacterium species are catalase-positive Gram-positive bacilli, also known as "diphtheroids" or "coryneform" bacteria, were once almost universally dismissed as contamination when recovered from patients, but they are now increasingly being linked to serious infections and have the ability to form biofilms and rarely cause CIED infections and this can be complicated as infective endocarditis. Corynebacterium spp. are frequently overlooked as contaminants in blood cultures, yet they can cause a serious infective endocarditis (IE). Antibiotic resistance is increasing among Corynebacterium spp., and this makes treatment more challenging. There are few reports of IE caused by Corynebacterium spp., and more research is needed. Here, we report a case of 55- year old man with Corynebacterium spp. cardiac device-related infective endocarditis.


Corynebacterium; Endocarditis; Cardiac implantable electronic device


Las infecciones por dispositivos electrónicos implantables cardíacos (CIED) han ido en aumento en todo el mundo. Muchos microorganismos pueden conducir esta enfermedad. Las especies de Corynebacterium son bacilos grampositivos catalasa positivos, también conocidos como bacterias "difteroides" o "corineformes" que, alguna vez, se descartaron casi universalmente como contaminación cuando se recuperaron de los pacientes, pero ahora se los vincula cada vez más con infecciones graves y tienen la capacidad de forman biopelículas y rara vez causan infecciones por CIED, y esto puede complicarse como una endocarditis infecciosa. Corynebacterium spp. a menudo se pasan por alto como contaminantes en los hemocultivos, pero pueden causar una endocarditis infecciosa (EI) grave. La resistencia a los antibióticos está aumentando entre Corynebacterium spp., y esto hace que el tratamiento sea más desafiante. Hay pocos informes de EI causada por Corynebacterium spp., y se necesita más investigación. Aquí reportamos un caso de un hombre de 55 años con EI por Corynebacterium spp. relacionada con dispositivos cardíacos.

Palabras clave

Corynebacterium; Endocarditis; Dispositivos electrónicos implantables cardiacos


1. Zasada AA, Mosiej E. Contemporary microbiology and identification of Corynebacteria spp. causing infections in human. Lett Appl Microbiol. 2018;66(6):472-83. doi: 10.1111/lam.12883.
2. Bernard K. The genus corynebacterium and other medically relevant coryneform-like bacteria. J Clin Microbiol. 2012;50(10):3152-8. doi: 10.1128/JCM.00796-12.
3. Şimşek-Yavuz S, Akar AR, Aydoğdu S, Berzeg Deniz D, Demir H, Hazırolan T, et al. Diagnosis, treatment and prevention of infective endocarditis: Turkish consensus report-2019. Turk Kardiyol Dern Ars. 2020;48(2):187-226. English. doi: 10.5543/tkda.2020.89689.
4. Kusumoto FM, Schoenfeld MH, Wilkoff BL, Berul CI, Birgersdotter-Green UM, Carrillo R, et al. 2017 HRS expert consensus statement on cardiovascular implantable electronic device lead management and extraction. Heart Rhythm. 2017;14(12):e503-e551. doi: 10.1016/j.hrthm.2017.09.001.
5. Bongiorni MG, Tascini C, Tagliaferri E, Di Cori A, Soldati E, Leonildi A, et al. Microbiology of cardiac implantable electronic device infections. Europace. 2012;14(9):1334-9. doi: 10.1093/europace/eus044.
6. Jędrzejczyk-Patej E, Mazurek M, Kowalski O, Sokal A, Kozieł M, Adamczyk K, et al. Device-related infective endocarditis in cardiac resynchronization therapy recipients - Single center registry with over 2500 person-years follow up. Int J Cardiol. 2017;227:18-24. doi: 10.1016/j.ijcard.2016.11.029.
7. Melo N, Correia C, Gonçalves J, Dias M, Garcia RM, Palma P, et al. Corynebacterium striatum cardiac device-related endocarditis: A case report. IDCases. 2021;27:e01371. doi: 10.1016/j.idcr.2021.e01371.
8. Serpa Pinto L, Dias Frias A, Franca M. Corynebacterium striatum Cardiac Device-Related Infective Endocarditis: The First Case Report in a Patient With a Cardiac Resynchronization Therapy Defibrillator Device and Review of the Literature. J Med Cases. 2021;12(2):61-4. doi: 10.14740/jmc3618.
9. Sandoe JA, Barlow G, Chambers JB, Gammage M, Guleri A, Howard P, et al. Guidelines for the diagnosis, prevention and management of implantable cardiac electronic device infection. Report of a joint Working Party project on behalf of the British Society for Antimicrobial Chemotherapy (BSAC, host organization), British Heart Rhythm Society (BHRS), British Cardiovascular Society (BCS), British Heart Valve Society (BHVS) and British Society for Echocardiography (BSE). J Antimicrob Chemother. 2015;70(2):325-59. doi: 10.1093/jac/dku383.
10. Johansen JB, Jørgensen OD, Møller M, Arnsbo P, Mortensen PT, Nielsen JC. Infection after pacemaker implantation: infection rates and risk factors associated with infection in a population-based cohort study of 46299 consecutive patients. Eur Heart J. 2011;32(8):991-8. doi: 10.1093/eurheartj/ehq497.
11. Biscarini S, Colaneri M, Mariani B, Pieri TC, Bruno R, Seminari E. A case of Corynebacterium striatum endocarditis successfully treated with an early switch to oral antimicrobial therapy. Infez Med. 2021;29(1):138-44.
12. Gupta R, Popli T, Ranchal P, Khosla J, Aronow WS, Frishman WH, et al. Corynebacterium Jeikeium Endocarditis: A Review of the Literature. Cardiol Rev. 2021;29(5):259-62. doi: 10.1097/CRD.0000000000000355.
13. Bläckberg A, Falk L, Oldberg K, Olaison L, Rasmussen M. Infective Endocarditis Due to Corynebacterium Species: Clinical Features and
Antibiotic Resistance. Open Forum Infect Dis. 2021;8(3):ofab055. doi: 10.1093/ofid/ofab055.
14. Abi R, Ez-Zahraouii K, Ghazouani M, Zohoun A, Kheyi J, Chaib A, et al. [A Corynebacterium striatum endocarditis on a carrier of pacemaker]. Ann Biol Clin (Paris). 2012;70(3):329-31.. doi: 10.1684/abc.2012.0707.
15. Oliva A, Belvisi V, Iannetta M, Andreoni C, Mascellino MT, Lichtner M, et al. Pacemaker lead endocarditis due to multidrug-resistant Corynebacterium striatum detected with sonication of the device. J Clin Microbiol. 2010;48(12):4669-71. doi: 10.1128/JCM.01532-10.

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